Muhimbili National Hospital -Mloganzila has eight (8) Directorates with six (6) units named;

1. Directorate of Medical Services
2. Directorate of Surgical Services
3. Directorate of Clinical Support Services
4. Directorate of Nursing and Housekeeping Services
5. Directorate of Technical Services
6. Directorate of Finance and Planning
7. Directorate of Human Resources

Six units under the Executive Director are;

1. Procurement Management Unit
2. Information and Communication Technology
3. Legal Services Unit
4. Corporate Communication and Customer Care
5. Internal Audit Unit
6. Research, Training and Consultancy Unit.
7. Quality Assurance Unit